What is it about?
A total of 20% of patients receiving high-dose CP have severe renal dysfunction.
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Why is it important?
Azadirachta indica can be considered a potential candidate for protection of nephrotoxicity induced by cisplatin.
Perspectives
The oral administration of MLEN to CP-intoxicated rats for 5 days brought back MDA, NO production, and enzymatic and nonenzymatic antioxidants to near normalcy. Moreover, the histological observations evidenced that neem extract effectively rescues the kidney from CP-mediated oxidative damage. Furthermore, PCR results for caspase-3 and caspase-9 and Bax genes showed downregulation in MLEN treated groups.
Professor Ahmed E Abdel Moneim
Helwan University
Read the Original
This page is a summary of: Azadirachta indicaAttenuates Cisplatin-Induced Nephrotoxicity and Oxidative Stress, BioMed Research International, January 2014, Hindawi Publishing Corporation,
DOI: 10.1155/2014/647131.
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