What is it about?

This review covers some of the most striking microRNA functions involved in morphine tolerance and presents limitations on our knowledge of their physiological roles.

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Why is it important?

Morphine tolerance is an adaptive process induced by chronic morphine that has been shown to result from complex alterations at the molecular level with μ opioid receptors (MORs), as well as at the synaptic, cellular, and circuit levels. MicroRNAs are noncoding RNAs that have been proposed to regulate gene expression and degradation at the posttranscriptional level, including the MOR, as well as synaptic plasticity and neuroplasticity, in both the peripheral and central nervous systems.


In summary, the molecular mechanisms of miRNAs participating in morphine tolerance are complex, and the use of miRNAs as targets for morphine tolerance may be a potential therapeutic approach but will face many challenges.

Tengjiao Zhang
Beijing Hospital

Read the Original

This page is a summary of: The Emerging Perspective of Morphine Tolerance: MicroRNAs, Pain Research and Management, April 2019, Hindawi Publishing Corporation,
DOI: 10.1155/2019/9432965.
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