What is it about?

The oxidative stress response following Transcatheter Aortic Valve Replacement -TAVR- a minimally invasive, no surgical procedure to replace the aortic valve, has not been described. Changes in reactive oxygen species were prospectively compared in 38 patients undergoing TAVR and 22 patients undergoing standard surgical AVR.

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Why is it important?

TAVR as compared to SAVR appears not to cause acute oxidative stress and may even improve the antioxidant capacity in the extracellular compartment. This remains after adjustment by covariables despite the fact that patients undergoing TAVR had greater comorbidities and impaired baseline antioxidant defenses han those undergoing SAVR.


Larger studies would be required to determine if these potentially beneficial alterations are associated with clinical outcomes in patients undergoing TAVR.

Gabriel Maluenda
Universidad de Chile

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This page is a summary of: Early Oxidative Stress Response in Patients with Severe Aortic Stenosis Undergoing Transcatheter and Surgical Aortic Valve Replacement: A Transatlantic Study, Oxidative Medicine and Cellular Longevity, November 2019, Hindawi Publishing Corporation, DOI: 10.1155/2019/6217837.
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