What is it about?

The treatment of anterior cruciate ligament (ACL) injuries in children and adolescents is challenging. Preclinical and clinical studies investigated ACL repairing techniques in skeletally immature subjects. However, intra-articular bioenvironment following ACL tear has not yet been defined in skeletally immature patients. The aim of this study was to measure cytokine concentrations in the synovial fluid in adolescent population.

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Why is it important?

Skeletally immature patients with meniscal tears and open growth plates have a characteristic cytokine profile with particularly elevated levels of proinflammatory cytokines including IL-8, TNF-α, and IL-1β. This picture suggests that the ACL tear could promote an intra-articular catabolic response in adolescent patients greater than that generally reported for adult subjects. The study lacks the comparison with synovial samples from healthy skeletally immature knees due to ethical reasons. Overall, these data contribute to a better knowledge of adolescent intra-articular bioenvironment following ACL injuries


Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to a greater involvement in Pediatric Sport Medicine research.

Dr Marco Turati
Universita degli Studi di Milano-Bicocca

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This page is a summary of: Intra-Articular Cytokine Levels in Adolescent Patients after Anterior Cruciate Ligament Tear, Mediators of Inflammation, August 2018, Hindawi Publishing Corporation,
DOI: 10.1155/2018/4210593.
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