What is it about?
The manuscript evidences the acquired oxidative damage in DNA (8-oxoG) and the cleavage of single strands of DNA through human adipogenesis. At the same time, the loss of reparative capacity of DNA in adipogenesis is shown.
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Why is it important?
The study is important because it is one of the few works of follow-up of the adipogenic process that shows alterations in DNA repair challenged by hydrogen peroxide in concentrations similar to those that occur under wound conditions. The loss of reparative capacity of DNA in adipogenic differentiation demonstrates the risk of acquiring genomic instability.
Read the Original
This page is a summary of: Hydrogen Peroxide-Induced DNA Damage and Repair through the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells, Stem Cells International, October 2018, Hindawi Publishing Corporation, DOI: 10.1155/2018/1615497.
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