Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy

What is it about?

The beneficial and adverse effects of pharmacological treatments of sleep-wake disorders are often variable and in part genetically determined. This overview discusses the currently known impact of genetic variants affecting exposure of and sensitivity to drugs targeting the neurochemistry of sleep-wake regulation and the pathophysiology of sleep-wake disturbances and their possible relevance for precision sleep-wake medicine.

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Why is it important?

Sleep pharmacogenetics provides a powerful new tool to elucidate molecular mechanisms of sleep-wake regulation in humans, to understand inter-individual differences in safety and efficacy of sleep-wake therapies, and to develop possible novel treatment options for sleep-wake disorders which are highly prevalent in our (aging) society.