What is it about?
All organisms on earth need to adapt to changing CO2 concentrations. Pathogenic microbes, including fungi, can face dramatic changes in CO2 concentrations in their life cycle. Therefore they have developed a sophisticated signaling system that enables regulation of gene expression in response to available CO2. In our work, we have considerably broadened our understanding of this signaling pathway by showing that a specific kinase lins CO2 adaptation to lipid signaling.
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Why is it important?
The signaling cascade we analysed in our work is central for adaptation to einvironmental niches but also during human infection. Therefore new biological insight may in this case also reveal new targets for therapeutic approaches.
Perspectives
Although our data provide a new important link in signaling cascades governing environmental adaptation, they also raise new and interesting questions. In my personal view, the involvement of lipid signaling and its crosstalk with adaptation to environmental cues is a promising new line to follow.
Prof Oliver Kurzai
Leibniz Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut
Read the Original
This page is a summary of: Lipid Signaling via Pkh1/2 Regulates Fungal CO2 Sensing through the Kinase Sch9, mBio, January 2017, ASM Journals,
DOI: 10.1128/mbio.02211-16.
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