3' UTRs (untranslated regions) may help viruses hide

What is it about?

A new form of regulation of gene expression is uncovered for a persistent human tumor virus and this may be relevant to disease associated with this virus and the infectious cycles of numerous other pathogens.

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Why is it important?

Here we uncover a new mode of post-transcriptional regulation for the human tumor virus KSHV. Understanding how KSHV regulates differential gene expression in lytic versus latent infection is imperative to better understanding cancer and other disease associated with this virus. Furthermore, advancing our understanding of 3'UTR-mediated regulation is of interest to many fields in addition to cancer and virology.