What is it about?
Human hematopoietic stem cells block HIV-1 infection before integration of the viral DNA into the cell genome.
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Why is it important?
This block to infection has implications for the potential for HIV-1 reservoirs to extend to hematopoietic stem cells, and for gene therapy efforts utilizing lentiviral vectors in these cells.
Perspectives
This block is distinct from, or in addition to, blocks seen in mouse hematopoietic stem cells.
Professor Stephen P Goff
Columbia University
Read the Original
This page is a summary of: HIV-1 Is Restricted prior to Integration of Viral DNA in Primary Cord-Derived Human CD34+Cells, Journal of Virology, May 2015, ASM Journals,
DOI: 10.1128/jvi.01044-15.
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