What is it about?
The host antiviral factor TRIM6, which is involved in IFN signaling, is hijacked by the Ebola virus VP35 protein resulting in increased Ebola virus replication
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Why is it important?
This is a novel mechanism used by Ebola virus to evade the innate immune response and at the same time enhance it ability to replicate in its host. This indicates that TRIM6 could represent a potential target in the development of antiviral drugs against Ebola virus infection.
Perspectives
This work identified an ubiquitination site (K309) on Ebola virus VP35 protein, previously known to be important for binding to double-stranded RNA. This suggests that ubiquitination of VP35 may affect its IFN antagonist function as well as potential functions in viral RNA transcription/replication.
Ricardo Rajsbaum
University of Texas Medical Branch
Read the Original
This page is a summary of: The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication, Journal of Virology, July 2017, ASM Journals,
DOI: 10.1128/jvi.00833-17.
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