What is it about?
A small molecule, known a pyrrole-imidazole-based polyamide, was found to inhibit Vesicular Stomatitis Virus (VSV) infections in cells. The crystal structure of the small molecule inhibitor was determined bound to RNA and a nucleocapsid-like particle. The structure shows that the active compound is bound to both RNA and protein. Biophysical measurements indicated that the melting temperature (stability) of the nucleocapsid-like particle (NLP) was affected by the presence of the active compound. Interestingly, polyamides were previously reported to bind poorly to RNA by two groups.
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Why is it important?
This is the first example of a polyamide acting against the RNA of an RNA virus rather than a subsequent DNA form. VSV is a model for other viruses that are clinically important.
Read the Original
This page is a summary of: A Polyamide Inhibits Replication of Vesicular Stomatitis Virus by Targeting RNA in the Nucleocapsid, Journal of Virology, February 2018, ASM Journals,
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