Fully Automated Quantification of Cytomegalovirus (CMV) in Whole Blood with the New Sensitive Abbott RealTime CMV Assay in the Era of the CMV International Standard

N. Schnepf, C. Scieux, M. Resche-Riggon, L. Feghoul, A. Xhaard, S. Gallien, J.-M. Molina, G. Socie, D. Viglietti, F. Simon, M.-C. Mazeron, J. LeGoff
  • Journal of Clinical Microbiology, April 2013, ASM Journals
  • DOI: 10.1128/jcm.00067-13

Evaluation of Abbott RealTime CMV in Whole Blood

What is it about?

Fully standardized reproducible and sensitive quantification assays for cytomegalovirus (CMV) are needed for antiviral therapy initiation and interruption. This articles describes the performances of an automated system for the quantification of CMV DNA in whole blood.

Why is it important?

The Abbott RealTime CMV assay detected and quantified, respectively, 20.6% and 47.8% more samples than the method of reference. The sensitivity and reproducibility of the results fulfilled the quality requirements for its implementation in clinical settings. Our results emphasize also the need for careful validation of conversion factors provided by the manufacturers for the WHO international standard in whole blood.

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The following have contributed to this page: Jerome Le Goff