Signal that directs protein to membrane

What is it about?

We found that GPI anchoring is an important modification to ensure proper localization of membrane or cell wall proteins, which is one of mechanism for polarized growth in filamentous fungi.

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Why is it important?

GPI anchoring is one of post-translation modification and has been investigated for a long time. GPI anchoring is known as a signal to direct proteins to the plasma membrane and also a pathway for some secreted proteins. In our paper, we found the signal to direct the localization of membrane or cell proteins, especially for membrane bound glucan synthetases or cell wall proteins, which are essential for cell wall integrity and polarized growth of filamentous fungi.