Oligonucleotide-Lipid Conjugates Forming G-Quadruplex Structures Are Potent and Pangenotypic Hepatitis C Virus Entry Inhibitors In Vitro and Ex Vivo

George Koutsoudakis, Alexia Paris de León, Carolina Herrera, Marcus Dorner, Gemma Pérez-Vilaró, Sébastien Lyonnais, Santiago Grijalvo, Ramon Eritja, Andreas Meyerhans, Gilles Mirambeau, Juana Díez
  • Antimicrobial Agents and Chemotherapy, February 2017, ASM Journals
  • DOI: 10.1128/aac.02354-16

Antiviral activity of lipid-DNA molecules

What is it about?

Drugs composed of a DNA fragment and a lipid are able to block the entry of hepatitis C virus in liver cells. The DNA fragment has a special sequence that increases the efficacy of the inhibition.

Why is it important?

Hepatitis C virus is responsable of a life-threatening disease. The novel drug inhibit the recognition event between the capside viral protein and the membrane receptors of the hepatic cells. This mechanism can be used for the design of novel antiviral drugs.

Perspectives

Ramon Eritja
CSIC

The work is the first publication of a research involving several groups from an idea generated by nucleoprotein experts Dr. Giles Mirambeau and Dr. Sebastien Lyonnais.

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http://dx.doi.org/10.1128/aac.02354-16

The following have contributed to this page: Ramon Eritja

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