What is it about?
We evaluated antibodies that can neutralize many types of HIV for their capacity to prevent HIV infection in cervical and colon in vitro tissue models. We showed that the more potent the antibody, the less amount was needed to prevent HIV infection in both tissue models. Of interest, less antibody was needed for colon tissue as compared to cervical tissue.
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Why is it important?
Our data provide a proof-of-concept that antibodies when applied topically can prevent HIV infection of tissues that likely are the first to encounter HIV through sex.
Perspectives
This was a nice paper to get published as this brings our lab work to the bed-side. Some of these antibodies are being considered for HIV prevention options.
Dr Charlene S. Dezzutti
University of Pittsburgh
Read the Original
This page is a summary of: Broadly Neutralizing Anti-HIV Antibodies Prevent HIV Infection of Mucosal TissueEx Vivo, Antimicrobial Agents and Chemotherapy, November 2015, ASM Journals,
DOI: 10.1128/aac.02097-15.
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