Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection

  • Sean Ekins, Mary A. Lingerfelt, Jason E. Comer, Alexander N. Freiberg, Jon C. Mirsalis, Kathleen O'Loughlin, Anush Harutyunyan, Claire McFarlane, Carol E. Green, Peter B. Madrid
  • Antimicrobial Agents and Chemotherapy, November 2017, ASM Journals
  • DOI: 10.1128/aac.01711-17

Finding an old drug that works against ebola

What is it about?

The focus of this work is testing the small molecule drug tilorone against the mouse infection model for ebola. We also provide some in vitro data on this old drug.

Why is it important?

Ebola has a high fatality rate and there are currently no approved drugs or vaccines. The compound is a known antiviral approved in Russia and several other countries. It is already used against some viruses.

Perspectives

Dr Sean Ekins
Collaborations in Chemistry

We discovered tilorone using machine learning in 2015. This publication suggests the molecule could be worth further evaluation.

Read Publication

http://dx.doi.org/10.1128/aac.01711-17

The following have contributed to this page: Dr Sean Ekins