Candida albicans Mucin Msb2 Is a Broad-Range Protectant against Antimicrobial Peptides

  • Marc Swidergall, Andreas M. Ernst, Joachim F. Ernst
  • Antimicrobial Agents and Chemotherapy, June 2013, ASM Journals
  • DOI: 10.1128/aac.00862-13

C. albicans Mucin Msb2

Why is it important?

This paper quantitates for the first time the interaction of Msb2, a secretory protein of the fungal pathogen Candida albicans, with a human antimicrobial peptide (AMP). The measurements were done by a novel method, microscale thermophoresis (MST) and show high affinity of binding, which explains the phenomenon that Msb2 protects microorganisms against AMPs, specifically against the reserve antibiotic daptomycin.

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The following have contributed to this page: Dr Marc Swidergall