Cholesterol production and how it influences liver cancer.
What is it about?
This Focus piece highlights the recent finding that a key enzyme involved in cholesterol synthesis, squalene monooxygenase (SM), has a key role in the development of liver cancer. This piece highlights the original work published in the same issue of Science Translational Medicine.
Why is it important?
Cholesterol has diverse roles and now, we know high cholesterol is associated with a number of cancers. This reliance of cancer cells on cholesterol means we have another way to target cancer cells. Here, we highlight that squalene monooxygenase (SM) increases cholesterol production and also reactive oyxgen species. These feed into a pathway that results in liver cancer progression. This novel finding by Liu et al. provides as a new mechanism to understand liver cancer and how cholesterol makes liver cancer worse.
The following have contributed to this page: Mr Ngee Kiat (Jake) Chua