Regeneration od a bioengineered 3D integumentary organ system from iPS cells

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Organ generation, which is a complex process of organogenesis during embryogenesis, is a next-generation of regenerative medicine. In our study, we succeed to reproduce of skin development during embryogenesis and regenerate skin field, 3D integumentary system including skin appendages from iPS cells. Our present outcomes indicate a proof of concept of regenerative therapy of fully functional and integrated skin organ system that will have a potential for the application of the future clinical treatment. Importantly, to regenerate 3D integumentary organ system, it is essential to mimic to the developmental process of skin field. These skin appendage organs arise from their organ germs, which are induced by reciprocal epithelial and mesenchymal interactions, in the skin field. Thus, we thought that the induction of immature epithelial and mesenchymal tissues of skin field in iPS cells is essential. Furthermore, to induce skin appendage organs, we induced organogenesis by using Wnt10b-signalling, which plays important roles for hair follicle development during embryogenesis.

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