What is it about?

Major site of morphine analgesia is known to be in the brain. Morphine analgesia is strong against acute pain, but is largely attenuated in chronic pain. Although opioid receptor expression in peripheral neurons decreases in the case of nerve injury-induced neuropathic pain in mice, brain morphine analgesia is lost in stress-induced mouse fibromyalgia model. Proposed mechanism is the opioid tolerance to intensively released endogenous opioids following repeated stress.

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Why is it important?

Opioids are not always strong pain killers.

Perspectives

The proposed message comes from animal studies. I hope to hear the suggestions from clinical studies on this report.

Hiroshi Ueda
Kyoto Daigaku

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This page is a summary of: NR2A-NMDA Receptor Blockade Reverses the Lack of Morphine Analgesia Without Affecting Chronic Pain Status in a Fibromyalgia-Like Mouse Model, Journal of Pharmacology and Experimental Therapeutics, January 2020, American Society for Pharmacology & Experimental Therapeutics (ASPET), DOI: 10.1124/jpet.119.262642.
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