What is it about?
Prolonged strenuous exercise training may be associated with increased risk of cardiac arrhythmia and even primary cardiac arrest or sudden death. Given that the current evidence is promising, we hypothesized that prolonged strenuous exercise would induce cardiac disturbances (electrical, structural and biochemical) and that leucine supplementation would prevent, or at least mitigate, those outcomes.
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Why is it important?
Here we report, for the first time, that leucine supplementation not only fails to prevent symptoms of cardiac fatigue, but may also aggravate prolonged strenuous exercise-induced cardiovascular disturbances in trained rats. Furthermore, we find that exercising until exhaustion can cause cardiac electrical disturbances and cardiac myocyte damage.
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This page is a summary of: Long-term leucine supplementation aggravates prolonged strenuous exercise-induced cardiovascular changes in trained rats, Experimental Physiology, June 2016, Wiley,
DOI: 10.1113/ep085704.
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