What is it about?

Calcium is a key component in linking microenvironmental signals to the biomechanical pathways in the cell. However, the reported relationship between calcium and these pathways is contradictory. In this study, we developed a mathematical model that connects calcium signaling to YAP/TAZ as a major biomechanical pathway. Using the model, we predicted a context-specific relationship between calcium signaling and YAP/TAZ that depends on calcium dynamics, frequency of stimulating the cell, and the bistable response of CaMKII.

Featured Image

Why is it important?

Our model predicts the mechanisms that could explain the contradictory role of calcium in the activation of biomechanical pathways in the cell.

Read the Original

This page is a summary of: Mechanisms underlying divergent relationships between Ca 2+ and YAP/TAZ signaling, The Journal of Physiology, December 2022, Wiley, DOI: 10.1113/jp283966.
You can read the full text:



The following have contributed to this page