What is it about?
Calcium is a key component in linking microenvironmental signals to the biomechanical pathways in the cell. However, the reported relationship between calcium and these pathways is contradictory. In this study, we developed a mathematical model that connects calcium signaling to YAP/TAZ as a major biomechanical pathway. Using the model, we predicted a context-specific relationship between calcium signaling and YAP/TAZ that depends on calcium dynamics, frequency of stimulating the cell, and the bistable response of CaMKII.
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Why is it important?
Our model predicts the mechanisms that could explain the contradictory role of calcium in the activation of biomechanical pathways in the cell.
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This page is a summary of: Mechanisms underlying divergent relationships between Ca
2+
and YAP/TAZ signaling, The Journal of Physiology, December 2022, Wiley,
DOI: 10.1113/jp283966.
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