What is it about?
Calcium is a key component in linking microenvironmental signals to the biomechanical pathways in the cell. However, the reported relationship between calcium and these pathways is contradictory. In this study, we developed a mathematical model that connects calcium signaling to YAP/TAZ as a major biomechanical pathway. Using the model, we predicted a context-specific relationship between calcium signaling and YAP/TAZ that depends on calcium dynamics, frequency of stimulating the cell, and the bistable response of CaMKII.
Photo by National Cancer Institute on Unsplash
Why is it important?
Our model predicts the mechanisms that could explain the contradictory role of calcium in the activation of biomechanical pathways in the cell.
Read the Original
This page is a summary of: Mechanisms underlying divergent relationships between Ca
and YAP/TAZ signaling, The Journal of Physiology, December 2022, Wiley, DOI: 10.1113/jp283966.
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