G1 and S phase arrest in Candida albicans induces filamentous growth via distinct mechanisms

What is it about?

Cell cycle arrest in Candida albicans activates signaling pathways that lead to the filament formation, but the pathways involved are unclear. Here, we demonstrate that G1 phase arrest by the depletion of the G1 cyclin Cln3 and S phase arrest by hydroxyurea treatment both activate the cAMP-PKA pathway but require distinct downstream mechanisms to induce filamentous growth.

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