Orthodontic tensile strain induces angiogenesis via type IV collagen degradation by matrix metalloproteinase-12

What is it about?

Remodeling of the blood vessels in periodontal ligament (the connective tissue between tooth root and alveolar bone) is mandatory during orthodontic tooth movement. In this paper, we discovered that orthodontic force induces MMP12, which degrades the type IV collagen, and accelerates blood vessel remodeling.

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