What is it about?
To clarify the course of endogenous insulin secretion in patients who satisfied the diagnosis criteria of acute-onset type 1 diabetes (type1A diabetes), we retrospectively investigated beta cell function after long-term follow-up in such patients.
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Why is it important?
Our study revealed that endogenous insulin secretion capacity in type 1 diabetes reduces rapidly during a few years after onset, more rapidly in patients whose onset were younger than 18 years old. Furthermore, it was shown that almost all patients lose their endogenous insulin secretion capacity completely during the course of the disease.
Perspectives
Our present study suggests that immune intervention for type 1A diabetes is recommended to be introduced shortly after the onset of disease. This article leads to the progress toward a cure for Type1 diabetes.
Sae Uno
Osaka University
Read the Original
This page is a summary of: Complete loss of insulin secretion capacity in type 1A diabetes patients during long-term follow up, Journal of Diabetes Investigation, November 2017, Wiley,
DOI: 10.1111/jdi.12763.
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