What is it about?

The eye is a window to the brain. In patients with multiple sclerosis this window permits insight to the disease process. The disease leaves scars. This is about a new type of scar in the back of the eye of patients who suffer from multiple sclerosis. The name of the scar is "PHOMS". PHOMS affect about 16% of patients with MS.

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Why is it important?

The novel type of scar described is important because presence of PHOMS implies two things. First, there is a transport system from the eye to the brain. Second, this transport system may be blocked in patients with multiple sclerosis. The name of the transport system is "glymphatic". The glymphatic system was discovered by the group of Maiken Nedergaard. These experiments rely on experimental tracer studies. The present work lends one important tool to glymphatic research in humans. It permits for rapid, patient friendly, non-invasive imaging.


To cast a friendly, non-invasive, glance into the window to the brain until the changing scenery in an individual patient suggests de novo development of PHOMS. Then have a good plan on how to measure pressures.

Mr axel petzold
University College London Institute of Neurology

Read the Original

This page is a summary of: Longitudinal development of PHOMS suggest a novel pathological pathway in MS, Annals of Neurology, May 2020, Wiley, DOI: 10.1002/ana.25782.
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