Structure of NADP+‐dependent glutamate dehydrogenase from Escherichia coli – reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases

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Why is it important?

Puzzles over varied modes of coenzyme recognition in the GDH family made it important to determine a high-resolution structure for an NADP+ dependent example. The E. coli GDH structure had been studied at low resolution 20 years earlier in a Sheffield-Leeds collaboration but was not taken to high resolution at that time.