Involvement of fibrocytes in asthma and clinical implications

What is it about?

This article is a critical review of studies on the evaluation of the trafficking and effector function of bone marrow-derived fibrocytes in asthma. It focuses on the clinical relevance and therapeutic implications of these investigations.

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Why is it important?

The article highlights important methodological issues and provides solutions at the analytical and clinical levels, which may allow the use of blood fibrocytes count as a biomarker of asthma control and therapeutic responsiveness. It propose a novel therapeutic approach to block persistent fibrocytosis in difficult-to-treat asthma.