Neonicotinoid insecticides differently modulate acetycholine-induced currents on mammalian α7 nicotinic acetylcholine receptors

What is it about?

Neonicotinoid insecticides are of particular interest because they are currently used in agriculture. Studies suggest that they are poor agonists of mammalian neuronal nicotinic acetylcholine receptors. We demonstrate that they differently act on mammalian nicotinic receptors and are able to modulate acetylcholine-evoked currents. Due to the function of acetylcholine on excitatory synaptic transmission, it is possible to consider that this modulatory effect could have physioloigical consequences on ACh-induced currents.

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