What is it about?

This article provides new insights into the importance of FN1 in cartilage tissue engineering to encourage more studies concerning FN1 in cartilage repair studies. Further, we provided new suggestions for advanced applications of FN1 to treat OA and cartilage degeneration.

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Why is it important?

Few studies reported the potential of FN1 to enhance tissue engineering and reduce the death of chondrocytes in OA. Further, FN1 possesses multiple binding domains including collagen, integrin, and heparin that can interact with heparan sulfate proteoglycans at the surface of chondrocytes leading to promoting cell signaling and differentiation.

Perspectives

Presents a new opportunity for using FN1 in clinical trials

Dr Murad Alahdal
Shenzhen University

Read the Original

This page is a summary of: Insights into the implementation of Fibronectin 1 in the cartilage tissue engineering, Biomedicine & Pharmacotherapy, April 2022, Elsevier, DOI: 10.1016/j.biopha.2022.112782.
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