CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1

What is it about?

Migraine is a prevalent neurological condition involving the neuropeptide CGRP. To test CGRP actions, we generated transgenic mice with an overexpressed human receptor subunit. Cell cultures revealed increased CGRP signaling and a partially humanized phenotype that suggests involvement of a non-canonical CGRP receptor on vascular smooth muscle and neurons.

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