What is it about?
We look into the functions of TRPM5, and review the knowledge about its involvement in the development of obestity and diabetes
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Why is it important?
Obesity and Diabetes are two linked metabolic disorders that are reaching pandemic proportions. Despite the best effort, no treatment or therapy seems to be able to prevent or treat these disorders with a sufficiently high adherence and succes rate. The costs of the health epidemic to patients and healthcare systems worldwide is huge, a better understanding of the disease mechanism and the possibility to target it on several levels might provide a positive worldwide health outcome.
Perspectives
The pharmacological targeting of TRPM5 could provide a preventive of curative therapy for type II diabetes, furthermore, it can reduce caloric intake and thereby reducing obesity, a dangerous comorbidity.
Koenraad Philippaert
Associatie KU Leuven
Read the Original
This page is a summary of: TRPM5 in the battle against diabetes and obesity, Acta Physiologica, October 2017, Wiley,
DOI: 10.1111/apha.12949.
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