NF-B expansion of myeloid derived suppressor cells

What is it about?

The results of our study suggest that both natural and accelerated models of aging drives an expansion in myeloid derived suppressors cells (MDSC), a cell type known to suppress both the adaptive and innate immune response, in part through a NF-κB dependent mechanism.

Featured Image

Why is it important?

Inflammation in the absence of an infection has deleterious effects. In the elderly, the heighten levels of MDSC make it difficult for the immune system to mount an immune response to infectious agents or cancerous growth. Thus, these cells could serve as a marker of advanced aging plus strategies may be developed to off set their abnormal expansion.