What is it about?
T cells are essential for inducing an antitumoral immune response, but tumors develop an adverse environment for the T cells, such as low O2 tension (hypoxia). We show for the first time that T cells infiltrating the pleura of lung cancer patients do not increase the expression of the glucose transporter Glut1; in consequence, T cells cannot take up glucose under hypoxia when they are stimulated.
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Why is it important?
Our findings show that even when T cells are properly stimulated, they cannot use glucose for their nutrimental needs in an hypoxic environment. In consequence, T cells cannot exert their antitumoral functions. Thus, lung cancer sabotages the metabolism of the T cells as a tumor evasion mechanism that might favor tumor survival.
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This page is a summary of: Deficient glucose uptake is linked to impaired Glut1 expression upon
28 stimulation in memory T cells from pleural effusions secondary to lung cancer, Scandinavian Journal of Immunology, July 2019, Wiley, DOI: 10.1111/sji.12802.
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CD8+ T cell dysfunction induced by lung carcinomas
This is a set of the articles that we have published concerning the study of defects in cytotoxic T cells from lung cancer patients
Supplemental Figure 1 from the article
Stimulation increase the expression of percentages of transferrin receptor (CD71) in T cells from nonmalignant and lung cancer patients.
Supplemental Figure 2 from the article
CD98 amino acid transporter is upregulated in T cells after stimulation
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