What is it about?

Periodontal regenerative therapy using bone-substituting materials has gained favorable clinical significance in enhancing osseous regeneration. We developed an injectable melatonin-loaded nano-sized β-TCP/hydrogel scaffold accelerates and promotes periodontal regeneration in class II furcation defects.

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Why is it important?

Our results indicate that the melatonin-treated group showed accelerated bone formation and advanced maturity, with a significant two-fold increase in newly formed inter-radicular bone compared to the unloaded composite. The short-term regenerative efficacy was evident four weeks postoperatively as a significant increase in cementum length concurrent with reduction of entrapped epithelium. After eight weeks, the scaffold produced a quality of newly synthesized bone similar to normal compact bone, with potent periodontal ligament attachment.


This work was a multidisciplinary collaborative effort with a team formed from a variety of disciplines and multiple centers, it was an immense pleasure and honor to collaborate with them all. Each and everyone added a significant plus to this work to appear as it is today. I wish this work attempts to bridge the gap between the ideal bone graft requirements and what we actually currently have.

Mohamed Abdelrasoul

Read the Original

This page is a summary of: Regeneration of critical‐sized grade II furcation using a novel injectable melatonin‐loaded scaffold, Oral Diseases, July 2022, Wiley,
DOI: 10.1111/odi.14314.
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