What is it about?
Periodontal regenerative therapy using bone-substituting materials has gained favorable clinical significance in enhancing osseous regeneration. We developed an injectable melatonin-loaded nano-sized β-TCP/hydrogel scaffold accelerates and promotes periodontal regeneration in class II furcation defects.
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Why is it important?
Our results indicate that the melatonin-treated group showed accelerated bone formation and advanced maturity, with a significant two-fold increase in newly formed inter-radicular bone compared to the unloaded composite. The short-term regenerative efficacy was evident four weeks postoperatively as a significant increase in cementum length concurrent with reduction of entrapped epithelium. After eight weeks, the scaffold produced a quality of newly synthesized bone similar to normal compact bone, with potent periodontal ligament attachment.
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This page is a summary of: Regeneration of
furcation using a novel injectable
scaffold, Oral Diseases, July 2022, Wiley,
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