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To identify proteins that bind to the inositol pyrophosphate 5-IP7, lysates prepared from amastigotes and epimastigotes of Trypanosoma cruzi in the presence of magnesium ions or EDTA were incubated with a non-hydrolysable 5-IP7 analog or a control reagent. Eluted proteins were identified by mass spectrometry and GO-terms analysis was done for all the resultant dataset hits. Based on protein identification data, some targets were chosen for validation in vitro.

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This page is a summary of: Affinity‐based proteomics reveals novel targets of inositol pyrophosphate (5‐IP 7 )‐dependent phosphorylation and binding in Trypanosoma cruzi replicative stages, Molecular Microbiology, January 2021, Wiley, DOI: 10.1111/mmi.14672.
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