What is it about?

To investigate the possible relationships between premature ejaculation (PE) polymorphisms in the dopamine transporter (DAT) gene (SLC6A3, DAT1), which has a polymorphic 40 base pair (40 bp) variable number of tandem repeats (VNTR) sequence in the 3'-untranslated region (3' VNTR).

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Why is it important?

Premature ejaculation (PE) is the most prevalent male sexual dysfunction, affecting up to 31% of men aged 18–59 years. Although some psychological, behavioural and biological aetiologies have been proposed, the exact pathophysiology of PE has not yet been clearly understood. The process of ejaculation is greatly influenced by genetic and neurobiological factors. Familial predisposition to PE was first reported by Schapiro in 1943. Waldinger et al . reported that 10 of 14 first-degree relatives of men with lifelong PE also experienced PE. As a result, the aetiology of PE is based on a genetic predisposition.


The prevalence of the genotypes and allele frequencies examined in the present study (9R and 10R) was highly consistent with several reports from Asian countries. Studies on Asian populations have shown that more than 90% of the Japanese, Mongolian and Korean populations have the 10R allele. In the present study, the patients with PE were more likely to have the 9/10 genotype and 9R allele than the control group. It has been reported that genetic and neurobiological factors determine the degree of the IELT. This means that PE is present throughout life and becomes apparent upon beginning sexual activity.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Relationship between premature ejaculation and genetic polymorphisms of the dopamine transporter gene (SLC6A3), BJU International, November 2010, Wiley,
DOI: 10.1111/j.1464-410x.2010.09809.x.
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