What is it about?

To investigate the association of the T-786C, G894T and variable number of tandem repeats (VNTRs) in intron 4 (a/b) polymorphisms of the eNOS gene in Iranian subjects with vasculogenic erectile dysfunction (ED).

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Why is it important?

Although mutations in the endothelial nitric oxide synthase gene have been extensively studied in cardiovascular diseases, there are limited data regarding its role in impotence . In the Turkish population, the CC genotype of the T-786C polymorphism was associated with an increased risk of impotence. The G894T polymorphism was also an independent risk factor for impotence in the same population. There are marked inter-ethnic differences in the distribution of endothelial nitric oxide synthase genetic variants. The frequency of T allele is considerably different among different ethnic groups. In addition, consideration of only one polymorphism rather than a combination of polymorphisms could bias the results. In other words, to obtain much more informative data, it is recommended that combinations of genetic markers are analysing, instead of testing the effects of genetic markers separately.


The findings of the present study highlight the significance of studying the biological pathways of gene polymorphisms in understanding factors related to ED. However, to date, our knowledge on the significance of genetic polymorphisms in influencing the vulnerability to, and severity of, impotence remains inadequate.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Association of the T-786C, G894T and 4a/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects, BJU International, October 2010, Wiley,
DOI: 10.1111/j.1464-410x.2010.09755.x.
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