What is it about?

We investigated the usefulness of oxygen nano-bubble water (O2NBW) as an oxygen-rich liquid for wound healing, by analyzing its effect on the wound-healing process in rats. The O2NBW group had a significantly higher epithelialisation rate and a significantly shorter number of epithelialisation days than control groups, in the ischaemia wound, in rats.

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Why is it important?

From a histopathological point of view, the O2NBW group of the ischaemic wound model group had less infiltration of inflammatory cells than the other test solution groups, and VG staining demonstrated that collagen fibres were arranged in the O2NBW group compared with the other test solution groups. From the fact that there were many collagen fibres and blood vessels, it is presumed that the oxygen supply by O2NBW was able to suppress the delay in wound healing.


We found that O2NBW used in topical oxygen therapy can promote ischaemic wound healing by stimulating collagen deposition and angiogenesis. Owing to device limitations, wound oxygen levels during and after treatment could not be measured. Therefore, the most beneficial oxygen levels and means of maintaining oxygen balance at various stages of wound healing have not yet been determined and should be investigated in the future.

Kohei Aoki
Tokyo Medical University Hospital

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This page is a summary of: Topical application of oxygen nano‐bubble water enhances the healing process of ischaemic skin wound healing in an animal model, International Wound Journal, April 2022, Wiley, DOI: 10.1111/iwj.13790.
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