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  1. Eluding the immune system's frontline defense: Secreted complement evasion factors of pathogenic Gram-positive cocci

    Article • Microbiological Research, December 2023, Elsevier

    Dr. Thomas Proft

  2. Different Group A Streptococcus pili lead to varying proinflammatory cytokine responses and virulence

    Article • Immunology and Cell Biology, October 2023, Wiley

    Dr. Thomas Proft

  3. Improvement of a vaccine candidate against Group A Streptococcus to cover more circulating strains

    Article • Immunology and Cell Biology, April 2023, Wiley

    Dr. Thomas Proft

  4. Design, optimization and evaluation of dexamethasone-loaded microneedles for inflammatory disorders

    Article • International Journal of Pharmaceutics, March 2023, Elsevier

    Dr. Thomas Proft

  5. Identification of an immunodominant region on a group A Streptococcus T-antigen reveals temperature-dependent motion in pili

    Article • Virulence, February 2023, Taylor & Francis

    Dr. Thomas Proft

  6. Enzymes that increase susceptibility to the antimicrobial enzyme lysozyme.

    Article • Microorganisms, January 2023, MDPI AG

    Dr. Thomas Proft

  7. Methods to Analyze the Contribution of Complement Evasion Factor (CEF) to Streptococcus pyogenes Virulence

    Article • January 2023, Springer Science + Business Media

    Dr. Thomas Proft

  8. Exploring ex vivo peptideolysis of thymopentin and lipid-based nanocarriers towards oral formulations

    Article • International Journal of Pharmaceutics, September 2022, Elsevier

    Dr. Thomas Proft

  9. Functional Characterisation of Two Novel Deacetylases from Streptococcus pyogenes

    Article • Microbiology Research, June 2022, MDPI AG

    Dr. Thomas Proft

  10. Pilus proteins from Streptococcus pyogenes stimulate innate immune responses through Toll‐like receptor 2

    Article • Immunology and Cell Biology, February 2022, Wiley

    Dr. Thomas Proft

  11. Complement evasion factor (CEF), a novel immune evasion factor of Streptococcus pyogenes

    Article • Virulence, January 2022, Taylor & Francis

    Dr. Thomas Proft

  12. Preformulation studies of thymopentin: analytical method development, physicochemical properties, kinetic degradation investigations and formulation perspective

    Article • Drug Development and Industrial Pharmacy, October 2021, Taylor & Francis

    Dr. Thomas Proft

  13. Intranasal immunization with Ag85B peptide 25 displayed on Lactococcus lactis using the PilVax platform induces antigen‐specific B‐ and T‐cell responses

    Article • Immunology and Cell Biology, May 2021, Wiley

    Dr. Thomas Proft

  14. Functional Analysis of Two Novel Streptococcus iniae Virulence Factors Using a Zebrafish Infection Model

    Article • Microorganisms, September 2020, MDPI AG

    Dr. Thomas Proft

  15. Development and Evaluation of a New Triplex Immunoassay That Detects Group A Streptococcus Antibodies for the Diagnosis of Rheumatic Fever

    Article • Journal of Clinical Microbiology, August 2020, ASM Journals

    Dr. Thomas Proft

  16. Nucleotidase enzymes in Gram-positive bacteria

    Article • Molecular Microbiology, January 2020, Wiley

    Dr. Thomas Proft, Kar Yan Soh

  17. Impact of Superantigen-Producing Bacteria on T Cells from Tonsillar Hyperplasia

    Article • Pathogens, June 2019, MDPI AG

    Dr. Thomas Proft

  18. Publisher Correction: Mucosal vaccination with pili from Group A Streptococcus expressed on Lactococcus lactis generates protective immune responses

    Article • Scientific Reports, May 2019, Springer Science + Business Media

    Dr. Thomas Proft

  19. Group A Streptococcus T Antigens Have a Highly Conserved Structure Concealed under a Heterogeneous Surface That Has Implications for Vaccine Design

    Article • Infection and Immunity, April 2019, ASM Journals

    Dr. Thomas Proft

  20. Orthologues of Streptococcus pyogenes nuclease A (SpnA) and Streptococcal 5′-nucleotidase A (S5nA) found in Streptococcus iniae

    Article • The Journal of Biochemistry, April 2018, Oxford University Press (OUP)

    Dr. Thomas Proft, Kar Yan Soh

  21. PilVax – a novel peptide delivery platform for the development of mucosal vaccines

    Article • Scientific Reports, February 2018, Springer Science + Business Media

    Dr. Thomas Proft

  22. Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity

    Article • Journal of Microbiology Immunology and Infection, November 2017, Elsevier

    Dr. Thomas Proft

  23. The ability of Group A streptococcus to adhere to immortalized human skin versus throat cell lines does not reflect their predicted tissue tropism

    Article • Clinical Microbiology and Infection, September 2017, Elsevier

    Dr. Thomas Proft

  24. Artificial Urine for Teaching Urinalysis Concepts and Diagnosis of Urinary Tract Infection in the Medical Microbiology Laboratory †

    Article • Journal of Microbiology and Biology Education, August 2017, ASM Journals

    Dr. Thomas Proft

  25. Mucosal vaccination with pili from Group A Streptococcus expressed on Lactococcus lactis generates protective immune responses

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Dr. Thomas Proft

  26. A potential role for staphylococcal and streptococcal superantigens in driving skewing of TCR Vβ subsets in tonsillar hyperplasia

    Article • Medical Microbiology and Immunology, May 2017, Springer Science + Business Media

    Dr. Thomas Proft

  27. Development of a high-throughput opsonophagocytic assay for the determination of functional antibody activity against Streptococcus pyogenes using bioluminescence

    Article • Journal of Microbiological Methods, March 2017, Elsevier

    Dr. Thomas Proft

  28. The Group A Streptococcus serotype M2 pilus plays a role in host cell adhesion and immune evasion

    Article • Molecular Microbiology, November 2016, Wiley

    Dr. Thomas Proft

  29. Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever

    Article • Frontiers in Microbiology, July 2016, Frontiers

    Dr. Thomas Proft

  30. Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing

    Article • Virulence, February 2016, Taylor & Francis

    Dr. Thomas Proft

  31. Streptococcal 5′-Nucleotidase A (S5nA), a NovelStreptococcus pyogenesVirulence Factor That Facilitates Immune Evasion

    Article • Journal of Biological Chemistry, November 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Thomas Proft

  32. Stabilized plasmid-based system for bioluminescent labeling of multiple streptococcal species

    Article • Biotechnology Letters, September 2015, Springer Science + Business Media

    Dr. Thomas Proft

  33. M-Protein Analysis of Streptococcus pyogenes Isolates Associated with Acute Rheumatic Fever in New Zealand

    Article • Journal of Clinical Microbiology, August 2015, ASM Journals

    Dr. Thomas Proft

  34. Increasing incidence of invasive group A streptococcus disease in New Zealand, 2002–2012: A national population-based study

    Article • Journal of Infection, February 2015, Elsevier

    Dr. Thomas Proft

  35. Survey of the bp/tee genes from clinical group A streptococcus isolates in New Zealand - implications for vaccine development

    Article • Journal of Medical Microbiology, September 2014, Society for General Microbiology

    Dr. Thomas Proft

  36. Vaccination with Streptococcus pyogenes nuclease A stimulates a high antibody response but no protective immunity in a mouse model of infection

    Article • Medical Microbiology and Immunology, August 2014, Springer Science + Business Media

    Dr. Thomas Proft

  37. Structure and Activity of Streptococcus pyogenes SipA: A Signal Peptidase-Like Protein Essential for Pilus Polymerisation

    Article • PLoS ONE, June 2014, PLOS

    Dr. Thomas Proft

  38. Working towards a Group A Streptococcal vaccine: Report of a collaborative Trans-Tasman workshop

    Article • Vaccine, June 2014, Elsevier

    Dr. Thomas Proft

  39. Structural Conservation, Variability, and Immunogenicity of the T6 Backbone Pilin of Serotype M6 Streptococcus pyogenes

    Article • Infection and Immunity, April 2014, ASM Journals

    Dr. Thomas Proft

  40. Streptococcal superantigens: categorization and clinical associations

    Article • Trends in Molecular Medicine, January 2014, Elsevier

    Dr. Thomas Proft

  41. Comparison of firefly luciferase and NanoLuc luciferase for biophotonic labeling of group A Streptococcus

    Article • Biotechnology Letters, December 2013, Springer Science + Business Media

    Dr. Thomas Proft

  42. Toxin–antitoxin-stabilized reporter plasmids for biophotonic imaging of Group A streptococcus

    Article • Applied Microbiology and Biotechnology, September 2013, Springer Science + Business Media

    Dr. Thomas Proft

  43. Galleria mellonellalarvae as an infection model for group A streptococcus

    Article • Virulence, July 2013, Taylor & Francis

    Dr. Thomas Proft

  44. Functional analysis of Streptococcus pyogenes nuclease A (SpnA), a novel group A streptococcal virulence factor

    Article • Molecular Microbiology, January 2011, Wiley

    Dr. Thomas Proft

  45. Crystal Structure of Spy0129, a Streptococcus pyogenes Class B Sortase Involved in Pilus Assembly

    Article • PLoS ONE, January 2011, PLOS

    Dr. Thomas Proft

  46. The use of sortase-mediated ligation for the immobilisation of bacterial adhesins onto fluorescence-labelled microspheres: a novel approach to analyse bacterial adhesion to host cells

    Article • Biotechnology Letters, July 2010, Springer Science + Business Media

    Dr. Thomas Proft

  47. Crystal Structure of the Minor Pilin FctB Reveals Determinants of Group A Streptococcal Pilus Anchoring

    Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Thomas Proft

  48. Purification, crystallization and preliminary crystallographic analysis of the minor pilin FctB fromStreptococcus pyogenes

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, January 2010, International Union of Crystallography

    Dr. Thomas Proft

  49. Isopeptide bonds in bacterial pili and their characterization by X-ray crystallography and mass spectrometry

    Article • Biopolymers, December 2009, Wiley

    Dr. Thomas Proft

  50. Sortase-mediated protein ligation: an emerging biotechnology tool for protein modification and immobilisation

    Article • Biotechnology Letters, September 2009, Springer Science + Business Media

    Dr. Thomas Proft

  51. The Laminin-Binding Protein Lbp from Streptococcus pyogenes Is a Zinc Receptor

    Article • Journal of Bacteriology, July 2009, ASM Journals

    Dr. Thomas Proft

  52. Pili in Gram-negative and Gram-positive bacteria — structure, assembly and their role in disease

    Article • Cellular and Molecular Life Sciences, October 2008, Springer Science + Business Media

    Dr. Thomas Proft

  53. The bacterial superantigen and superantigen-like proteins

    Article • Immunological Reviews, October 2008, Wiley

    Dr. Thomas Proft

  54. Immobilization of proteins to biacore sensor chips using Staphylococcus aureus sortase A

    Article • Biotechnology Letters, April 2008, Springer Science + Business Media

    Dr. Thomas Proft

  55. Purification, crystallization and preliminary crystallographic analysis ofStreptococcus pyogeneslaminin-binding protein Lbp

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, January 2008, International Union of Crystallography

    Dr. Thomas Proft

  56. Stabilizing Isopeptide Bonds Revealed in Gram-Positive Bacterial Pilus Structure

    Article • Science, December 2007, American Association for the Advancement of Science

    Dr. Thomas Proft

  57. The Cytokine Response to Streptococcal Superantigens Varies Between Individual Toxins and Between Individuals: Implications for the Pathogenesis of Group A Streptococcal Diseases

    Article • Journal of Interferon & Cytokine Research, July 2007, Mary Ann Liebert Inc

    Dr. Thomas Proft

  58. T cell stimulating toxins produced by the bacterial genus Streptococcus

    Article • January 2007, Karger Publishers

    Dr. Thomas Proft

  59. Different Preparations of Intravenous Immunoglobulin Vary in Their Efficacy to Neutralize Streptococcal Superantigens: Implications for Treatment of Streptococcal Toxic Shock Syndrome

    Article • Clinical Infectious Diseases, September 2006, Oxford University Press (OUP)

    Dr. Thomas Proft

  60. Streptococcal Mitogenic Exotoxin, SmeZ, Is the Most Susceptible M1T1 Streptococcal Superantigen to Degradation by the Streptococcal Cysteine Protease, SpeB

    Article • Journal of Biological Chemistry, September 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Thomas Proft

  61. Involvement of streptococcal superantigens in streptococcal toxic shock syndrome

    Article • International Congress Series, April 2006, Elsevier

    Dr. Thomas Proft

  62. Streptococcal superantigenic toxins

    Article • January 2006, Elsevier

    Dr. Thomas Proft

  63. Involvement of Streptococcal Mitogenic Exotoxin Z in Streptococcal Toxic Shock Syndrome

    Article • Journal of Clinical Microbiology, July 2005, ASM Journals

    Dr. Thomas Proft

  64. Variations in the protective immune response against streptococcal superantigens in populations of different ethnicity

    Article • Medical Microbiology and Immunology, June 2005, Springer Science + Business Media

    Dr. Thomas Proft

  65. Crystallographic and Mutational Data Show That the Streptococcal Pyrogenic Exotoxin J Can Use a Common Binding Surface for T-cell Receptor Binding and Dimerization

    Article • Journal of Biological Chemistry, July 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Thomas Proft

  66. Bacterial superantigens

    Article • Clinical & Experimental Immunology, September 2003, Wiley

    Dr. Thomas Proft

  67. Two Novel Superantigens Found in Both Group A and Group C Streptococcus

    Article • Infection and Immunity, March 2003, ASM Journals

    Dr. Thomas Proft

  68. The Three-dimensional Structure of a Superantigen-like Protein, SET3, from a Pathogenicity Island of theStaphylococcus aureusGenome

    Article • Journal of Biological Chemistry, June 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr. Thomas Proft

  69. Pyrogenicity and Cytokine-Inducing Properties ofStreptococcus pyogenes Superantigens: Comparative Study of Streptococcal Mitogenic Exotoxin Z and Pyrogenic Exotoxin A

    Article • Infection and Immunity, June 2001, ASM Journals

    Dr. Thomas Proft

  70. The Streptococcal Superantigen Smez Exhibits Wide Allelic Variation, Mosaic Structure, and Significant Antigenic Variation

    Article • The Journal of Experimental Medicine, May 2000, Rockefeller University Press

    Dr. Thomas Proft

  71. Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus pyogenes 1 1Edited by I. A. Wilson

    Article • Journal of Molecular Biology, May 2000, Elsevier

    Dr. Thomas Proft

  72. Superantigens – powerful modifiers of the immune system

    Article • Molecular Medicine Today, March 2000, Elsevier

    Dr. Thomas Proft

  73. Identification and Characterization of Novel Superantigens from Streptococcus pyogenes

    Article • The Journal of Experimental Medicine, January 1999, Rockefeller University Press

    Dr. Thomas Proft

  74. Article • Journal of Clinical Immunology, January 1999, Springer Science + Business Media

    Dr. Thomas Proft

  75. Superantigens: Just Like Peptides Only Different

    Article • The Journal of Experimental Medicine, March 1998, Rockefeller University Press

    Dr. Thomas Proft

  76. Sequence analysis and characterization of the hmw gene cluster of Mycoplasma pneumoniae

    Article • Gene, January 1996, Elsevier

    Dr. Thomas Proft

  77. The P200 protein of Mycoplasma pneumoniae shows common features with the cytadherence-associated proteins HMW1 and HMW3

    Article • Gene, January 1996, Elsevier

    Dr. Thomas Proft

  78. Identification and characterization of hitherto unknown Mycoplasma pneumoniae proteins

    Article • Molecular Microbiology, July 1994, Wiley

    Dr. Thomas Proft