What is it about?

We hypothesized that single nucleotide polymorphisms (SNPs) in Chemokine receptor 7 (CCR7) gene locus are associated with previous myocardial infarction in patients with coronary artery disease. To test this hypothesis, we genotyped six SNPs from the CCR7 gene locus in 300 consecutive patients, admitted for elective coronary angiography. Allele A of rs17708087 SNP was associated with previous MI. This association remained significant after adjustment for age, sex, smoking, hypercholesterolaemia and drugs used by patients (odds ratio 2.13, 95% confidence interval: 1.13–3.86).

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Why is it important?

The main conclusion of the presented study is that we identified a polymorphism rs17708087, located in the CCR7 gene locus, as associated with previous myocardial infarction in the population of patients from southern Poland, admitted to the hospital for elective coronary angiography.

Perspectives

The results suggest that this polymorphism is in the promoter flanking region, which is involved in binding of JunD. JunD is a member of AP-1 family of transcription factors, which among others have been demonstrated to play the role in NF-KB dependent activation of CCR7 expression. Whether this activity remains operational during myocardial infarction and whether studied polymorphism plays any role in modifying CCR7 expression remain to be determined

Leszek Drabik
Uniwersytet Jagiellonski w Krakowie

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This page is a summary of: Polymorphism in the chemokine receptor 7 gene (CCR7) is associated with previous myocardial infarction in patients undergoing elective coronary angiography, International Journal of Immunogenetics, June 2016, Wiley, DOI: 10.1111/iji.12270.
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