What is it about?
We hypothesized that single nucleotide polymorphisms (SNPs) in Chemokine receptor 7 (CCR7) gene locus are associated with previous myocardial infarction in patients with coronary artery disease. To test this hypothesis, we genotyped six SNPs from the CCR7 gene locus in 300 consecutive patients, admitted for elective coronary angiography. Allele A of rs17708087 SNP was associated with previous MI. This association remained significant after adjustment for age, sex, smoking, hypercholesterolaemia and drugs used by patients (odds ratio 2.13, 95% confidence interval: 1.13–3.86).
Photo by Robina Weermeijer on Unsplash
Why is it important?
The main conclusion of the presented study is that we identified a polymorphism rs17708087, located in the CCR7 gene locus, as associated with previous myocardial infarction in the population of patients from southern Poland, admitted to the hospital for elective coronary angiography.
Read the Original
This page is a summary of: Polymorphism in the chemokine receptor 7 gene (CCR7) is associated with previous myocardial infarction in patients undergoing elective coronary angiography, International Journal of Immunogenetics, June 2016, Wiley,
You can read the full text:
C-C chemokine receptor type 7 and C-C motif chemokine 19 polymorphism and angiographic patterns of coronary arteryatherosclerosis
INTRODUCTION. The aim of the study was to search for association between polymorphisms in the genes for C-C chemokine receptor type 7 and C-C motif chemokine 19 and angiographic patterns of coronary artery atherosclerosis or myocardial infarction risk in Polish population. METHODS. 300 patients with chronic stable coronary artery disease undergoing coronarography were genotyped by RFLP method and reverse dot blot hybridization. Single variable analysis for genotype-phenotype association involved chi-square test for additive, dominant and recessive model of inheritance, Fisher’s exact test, Cochran-Armitage trend test. Multivariate analysis involved linear regression and logistic regression RESULTS: Allele A rs17708087 frequency in patient who underwent myocardial infarction was significantly higher (75,5%) than in control group (59%, p=0,01). AA homozygotes versus other genotype carriers presented over two-fold increased risk of myocardial infarction (OR 2,13, CI 1,13-3,86). No correlation was found between CCR7, CCL19 polymorphisms and angiographic patterns of coronary artery atherosclerosis. CONCLUSIONS: The results of the study suggest that polymorphism rs17708087 may be potentially a risk factor of myocardial infarction in Polish population. Risk prediction models for coronary artery disease with rs17708087 require further research.
The following have contributed to this page