What is it about?

This study is the first to report that maternal HPA and HLA class I antibodies are associated with reduced birthweight, among not only FNAIT neonates but also healthy neonates, suggesting that maternal alloimmune antibodies may affect fetal development.

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Why is it important?

It is well known that HPA-1a antibodies lead to fetal and neonatal alloimmune thrombocytopenia (FNAIT), and its association with reduced birthweight in boys has been reported. The aim of this study was to investigate the incidence of platelet antibodies among Chinese women and the impact of maternal alloimmune antibodies on birthweight among healthy neonates. Among 15 156 women, 1 008 (6.7%) were positive for platelet antibodies, and the incidences of platelet antibody positive were 1.2%, 1.9%, 1.6% and 2.0% among women with 1, 2, 3, and more than 3 pregnancies, respectively. The average birthweight of healthy neonates delivered by women who were positive for platelet antibodies, HLA class I antibodies or HPA antibodies was 161 483 g lower than that of neonates delivered by women who were negative for these antibodies (P0.001)


I hope readers can understand the research of alloimmune antibodies on the weight of healthy newborns.

Yang Xue

Read the Original

This page is a summary of: Maternal alloimmune antibodies against HPA and HLA class I antigens are associated with reduced birthweight among healthy neonates delivered by Chinese women, Acta Obstetricia Et Gynecologica Scandinavica, July 2022, Wiley,
DOI: 10.1111/aogs.14421.
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