What is it about?

Rice AKR4C14 is an aldo-keto reductase from Thai Jasmine rice (Oryza sativa L., indica type cultivar Kao Dok Mali 105) which is popular due to its unique fragrance, flavor and texture. This research work confirms the role of rice AKR4C14 in detoxification of methylglyoxal (MG) and malondialdehyde (MDA) which involved in stress response, thus functioning in detoxification of toxic aldehydes.

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Why is it important?

Detoxifying malondialdehyde (MDA) may be very important for rice plants from tropical regions, in which lipid peroxidation regularly occurs. Thus, rice AKR might be a good candidate in developing stress-tolerant rice and could play a vital role in agricultural technology.

Perspectives

Structural analysis reveals the stabilized open conformation and explains the preference of AKR4C14 for its straight-chain aldehyde substrate.

Dr. Chomphunuch Songsiriritthigul
Synchrotron Light Research Institute

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This page is a summary of: Structure–function study of AKR4C14, an aldo-keto reductase from Thai jasmine rice (Oryza sativaL. ssp.indicacv. KDML105), Acta Crystallographica Section D Structural Biology, April 2020, International Union of Crystallography, DOI: 10.1107/s2059798320004313.
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