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This work identifies a novel posttranscriptional mechanism that consists of frp1+ mRNA destabilization by Puf2 and Puf4 through Pumilio response elements (PREs) in the frp1+ 3’ untranslated region. The Puf2/Puf4-mediated decay of frp1+ mRNA ensures rapid inhibition of the reductive iron uptake, thereby protecting cells against excessive accumulation of iron.

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This page is a summary of: Fission yeast RNA‐binding proteins Puf2 and Puf4 are involved in repression of ferrireductase Frp1 expression in response to iron, Molecular Microbiology, October 2021, Wiley, DOI: 10.1111/mmi.14829.
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