Human ASIC1a mediates stronger acid‐induced responses as compared with mouse ASICIa

What is it about?

Acidosis is common in neurological diseases. One key neuronal acid receptor in the brain is a family of acid-sensing ion channels (ASICs). Studies in rodents have shown that ASICs play important roles in neuron function and acidosis-induced neuronal injury. However, little is known about ASIC expression and regulation in humans. This study examined ASIC expression and trafficking in acutely resected human cortical tissues, and explored molecular mechanisms underlying differential trafficking of human and mouse ASIC1a. Further, this study examined the differential impact of human and mouse ASIC1a in acid-induced injury in heterologous cells. The findings provide insight into interpreting the role of ASIC channels in acid-induced signaling and neuronal injuries in human brain.

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