What is it about?
Using beta-actin knockout Mouse Embryonic Fibroblasts, we showed the changes in the heterochromatin organization, which is associated with dramatic changes in genes involved in common cellular processes. Those gene programs changes lead to differential phenotypical cellular identity.
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Why is it important?
This study highlighted the importance of beta-actin especially in the nucleus to influence the chromatin organization and gene programs. This implies an essential function of beta-actin in the establishment of cell fate and identity.
Perspectives
Our study showed the loss of chromatin binding of BAF complex subunit Brg1with beta-actin as a partner. Further work needs to clarify at genomic level how other chromatin remodeling complexes such as Polycomb complex are affected without beta-actin in the nucleus.
Xin Xie
Read the Original
This page is a summary of: β-Actin–dependent global chromatin organization and gene expression programs control cellular identity, The FASEB Journal, March 2018, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201700753r.
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