What is it about?
Many pathogens require the disaccharide, trehalose, yet it isn't required or synthesized in mammals. Hence, the biochemical pathways to trehalose are of great interest in the development of new and novel therapeutics. This paper looks at the topology of trehalose-6-phosphate phosphatases (TPPs) and classifies them into 3 groups.
Why is it important?
New therapeutics for parasitic diseases are greatly needed and are generally not highly prioritized by the pharmaceutical industry. Inhibition of TPP could be a novel approach to new anti-parasitic compounds.
The following have contributed to this page: Dr Andreas Hofmann and Associate Professor Mark J Coster