What is it about?
In this paper, we discovered the novel regulatory mechanism of osteoclastogenesis, the activation of bone resorbing cells. The molecule Bach1 plays as an accelerator for the activation of bone resorbing cells.
Featured Image
Why is it important?
Inhibition of Bach1 would be therapeutic target for bone destructive disease, such as gum disease, osteoporosis, and rheumatoid arthritis.
Perspectives
Our results would be useful from the point of exploration of the novel target molecule (Bach1) for bone destructive disease therapy.
Hiroyuki Kanzaki
Tsurumi University
Read the Original
This page is a summary of: RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice, The FASEB Journal, November 2016, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201600826r.
You can read the full text:
Contributors
The following have contributed to this page
