What is it about?

Under certain special conditions, some people are required to live and work in non-24 h working/rest schedules such as in maritime operations, oil mining and some other industries. In this work, we have measured the changes in circadian rhythms, physiology and behavior of subjects living in sleep deprivation (SD) and non-24 h working/rest schedule (8 h-on/4 h-off).

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Why is it important?

Most organisms on the Earth possess circadian rhythms in their physiology and behavior that allow them to resonate with the cycling environment over a 24-h period. However, in human society, a substantial quantity of jobs require non-24 h working/rest or shift schedules, such as maritime operations, oil mining and some other industries. We have demonstrated that non-24 h working/rest schedules caused extensive alterations in circadian rhythms, sleep, alertness and metabolism. Moreover, we also have found that the composition and abundance of oral microbiota were changed in sleep deprivation and in the non-24 h working/rest condition. In addition, our findings also suggest that the Da Vinci sleep schedule might not work for most people.


In the future, we will continue to investigate how the non-24 h schedules affect circadian clock, physiology and cognition at the molecular level as well as the underlying mechanisms.

Jinhu Guo

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This page is a summary of: Sleep deprivation and a non–24-h working schedule lead to extensive alterations in physiology and behavior, The FASEB Journal, March 2019, Federation of American Societies For Experimental Biology (FASEB),
DOI: 10.1096/fj.201802727r.
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