What is it about?
Single-cell RNA sequencing (scRNA-seq) is a technique used to study the gene expression of individual cells. Several methods of scRNA-seq have been developed, including droplet-based, plate-based, hydrogel-based, and spatial transcriptomics.
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Why is it important?
scRNA-seq is crucial because it allows scientists to understand the unique properties and functions of individual cells within a tissue, which was previously not possible with older techniques that looked at mixed cell populations. This ability to pinpoint differences between cells is key in understanding complex biological processes and diseases. For instance, identifying rare cell types can lead to discoveries about disease mechanisms or potential new treatments.
Perspectives
The future of scRNA-seq is focused on overcoming current technical challenges, like improving accuracy, efficiency, and the ability to analyze a larger number of cells. As the technology continues to evolve, it will likely become a cornerstone in biomedical research, offering new ways to tackle complex biological questions and medical challenges.
Dr. Hui-Qi Qu
Children's Hospital of Philadelphia
Read the Original
This page is a summary of: Single-Cell RNA Sequencing Technology Landscape in 2023, Stem Cells, November 2023, Oxford University Press (OUP),
DOI: 10.1093/stmcls/sxad077.
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